Study of the probiotic potential of microorganisms isolated from fermented foods has been increasing, especially studies related\nto lactobacilli. In intestinal models, lactobacilli have demonstrated beneficial properties, such as anti-inflammatory activity and\nincreased antibody production, but the molecular mechanisms involving probiotic and antagonistic action as well as their effect\non human vaginal cells have not yet been fully elucidated. The aim of this study was to evaluate the functional and antagonistic\nproperties of three strains of lactobacilli isolated from cocoa fermentation (Lactobacillus fermentum 5.2, L. plantarum 6.2, and L.\nplantarum 7.1) against Gardnerella vaginalis. Our results show that the lactobacilli have potential use as probiotics, since they have\nhigh hydrophobicity and autoaggregation properties and effectively adhere to vaginal cells. Metabolites secreted into the culture\nmedium and whole cells of the strains under study are capable of interfering with the growth of G. vaginalis to different degrees.\nThe elucidation of the antagonistic mechanisms as well as their effect on human cells may be useful in the development of a product\ncontaining such microorganisms or products secreted by them.
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